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KMID : 0828520010050020151
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Journal of the Korean Geriatrics Society
2001 Volume.5 No. 2 p.151 ~ p.158
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Apolipoprotein E Polymorphism in Patients with Ischemic Cerebrovascular Disease
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박문호/Park MH
고성범/김병조/박민규/박건우/이대희/Koh SB/Kim BJ/Park MK/Park KW/Lee DH
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Abstract
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Background : The possible role of apolipoproten E(APOE for gene, apoE for protein) allele in atherosclerotic diseases is not clearly understood. For the putative role of APOE genotypes, we examined APOE polymorphism among patients with stroke. Methods : A total of 202 ischemic stroke patients were involed in this study. The genomic DNA was isolated from whole blood and the APOE alleles were determined by polymerase chain reaction, Results : The genotype of APOE ε3/3 was the most common allele in the stroke group and the control group. The frequencies of APOE ε2,ε3,ε4 allele in stroke group were 0.052, 0.851, and 0.097, respectively. There was no significant difference in APOE genotypes between the stroke group and the control group. No significnat associations were found for the APOE genotypes and the serum lipid profiles. Conclusion : These findings suggest that APOE was not related to the stroke.
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KEYWORD
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